Most women know (or remember) the uninvited friend who visits just before their period every month: the moodiness, bloating, insomnia, headaches, breast tenderness and other annoying symptoms. While as many as 75% of women experience disruptive symptoms related to premenstrual syndrome (PMS), only a small proportion, around 5-8%, are considered to have symptoms that are “clinically significant”. A comparable proportion, 3-8%, experience the most severe symptoms of Premenstrual Dysphoric Disorder (PMDD), which are mostly behavioral and addressed as a psychiatric disorder.

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